Shih-Hsin Kan Selected Research

Acetylglucosaminidase (NAGase)

1/2021	Biochemical evaluation of intracerebroventricular rhNAGLU-IGF2 enzyme replacement therapy in neonatal mice with Sanfilippo B syndrome.
9/2018	Genetically Corrected iPSC-Derived Neural Stem Cell Grafts Deliver Enzyme Replacement to Affect CNS Disease in Sanfilippo B Mice.
1/2018	Macrophage enzyme and reduced inflammation drive brain correction of mucopolysaccharidosis IIIB by stem cell gene therapy.
10/2014	Delivery of an enzyme-IGFII fusion protein to the mouse brain is therapeutic for mucopolysaccharidosis type IIIB.

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Shih-Hsin Kan Research Topics

Disease

7	Mucopolysaccharidosis I (Hurler Syndrome) 11/2020 - 10/2010
6	Mucopolysaccharidoses 01/2022 - 12/2013
6	Mucopolysaccharidosis III (Sanfilippo Syndrome) 01/2022 - 10/2014
3	Spinal Cord Compression 08/2014 - 10/2010
2	Lysosomal Storage Diseases (Lysosomal Storage Disease) 03/2018 - 01/2018
1	Cachexia 01/2022
1	Dyslipidemias (Dyslipidemia) 01/2022
1	Hyperthermia 01/2022
1	Hyperphagia (Overeating) 01/2022
1	Communicable Diseases (Infectious Diseases) 01/2022
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2020
1	Muscular Diseases (Myopathy) 01/2020
1	Glycogen Storage Disease Type II (Pompe's Disease) 01/2020
1	Central Nervous System Diseases (CNS Diseases) 09/2018
1	Cognitive Dysfunction 01/2018
1	Inflammation (Inflammations) 01/2018
1	Gliosis 01/2018
1	Dementia (Dementias) 10/2016
1	Alzheimer Disease (Alzheimer's Disease) 10/2016
1	Nervous System Diseases (Neurological Disorders) 10/2016
1	Lymphoma (Lymphomas) 01/2015
1	Joint Diseases (Joint Disease) 08/2014
1	Leukocytosis (Pleocytosis) 12/2013
1	type 2 Syndactyly 04/2003

Drug/Important Bio-Agent (IBA)

6	GlycosaminoglycansIBA 01/2021 - 10/2010
5	Heparitin Sulfate (Heparan Sulfate)IBA 01/2022 - 10/2014
4	alpha-N-acetyl-D-glucosaminidase (alpha-N-acetylglucosaminidase)IBA 01/2021 - 10/2014
4	Acetylglucosaminidase (NAGase)IBA 01/2021 - 10/2014
4	Iduronidase (alpha-L-Iduronidase)IBA 03/2018 - 10/2010
3	EnzymesIBA 09/2018 - 10/2014
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 10/2014
1	N-sulfoglucosamine sulfohydrolase (sulfamidase)IBA 01/2022
1	TrioleinIBA 01/2022
1	Pharmaceutical PreparationsIBA 01/2022
1	N-acetylglucosamine-6-sulfataseIBA 12/2021
1	Hexosaminidases (Hexosaminidase)IBA 01/2021
1	Mannose (D-Mannose)IBA 01/2021
1	Lysergic Acid Diethylamide (LSD)IBA 01/2021
1	LipidsIBA 11/2020
1	AcidsIBA 01/2020
1	alpha-Glucosidases (Acid Maltase)IBA 01/2020
1	Prednisolone (Predate)FDA LinkGeneric 01/2018
1	CytokinesIBA 01/2018
1	Cholinergic Agents (Cholinergics)IBA 10/2016
1	Prednisone (Sone)FDA LinkGeneric 08/2014
1	Immunoglobulin G (IgG)IBA 12/2013
1	Interleukin-5 (Interleukin 5)IBA 12/2013
1	polyalanineIBA 04/2003

Therapy/Procedure

6	Enzyme Replacement Therapy 01/2021 - 10/2010
1	Therapeutics 01/2020
1	Intravenous Infusions 01/2020
1	Stem Cell Transplantation 01/2015
1	Hematopoietic Stem Cell Transplantation 08/2014